Scientific Programme - Draft

14.00 - 16.00 Registration
15.00 - 17.00 BSDB Committee Meeting OC1.04
14.00 - 17.00 BSCB Committee Meeting OC1.06
16.00 - 18.00  Career Workshop (organised by Student & Post Doc Reps)
18.00 - 19.00  Dinner - Rootes Restaurant (Rootes Building) 
19.00 - 20.00

Plenary BSCB (BSCB Session) 
PL01 Denise Montell - University of California, Santa Barbara, US

Molecular mechanisms of collective, cooperative, cell-on-cell migration

Chair: Susana Godhino

20.00 - 20.30

Beddington Medal

PL02 David Munro - Univeristy of Edinburgh, Edinburgh UK

Mechanisms of kidney vascularisation and the roles of macrophages in renal development

Chair: Jim Smith

20.30 - 21.00

Women in Cell Biology Early Career Award Medal
PL03 Pleasantine Mill - MRC Human Genetics Unit, Edinburgh, UK

Cilia in Development & Disease: Dynamics, Diversity & Dogma

Chair: Anne Straube

21.00 onwards Student & Post Doc Social / Drinks Reception: Panorama Suite, Rootes Building

Sunday 7th April 2019


Monday 8th April 2019

9.00 - 12.30

Session 1: Genome Integrity & Regulation

Chair: Andrew McAinsh

9.00 - 9.30

S01 David Pellman - Dana-Farber Cancer Institute, Boston, USA

Mechanisms for Rapid Genome Evolution

9.30 - 10.00

S02 Aga Gambus – University of Birmingham, Birmingham, UK

Replisome disassembly at the termination of DNA replication

10.00 - 10.30

S03 Stephen West - The Francis Crick Institute – London, UK

Roles of the SMX and GEN1 Holliday junction resolvases in DNA strand break repair
10.30 - 11.00 Refreshment Break and Exhibition Viewing Time - Oculus Atrium (Main Campus)
11.00 - 11.30

S04 Genome Integrity & Regulation
Stephen Goff - Columbia University Medical Center/HHMI, New York, US

Silencing of retroviral gene expression

11.30 - 12.00

S05 Susana Chuva de Sousa Lopes, University of Leiden

Epigenetic dynamics of the human fetal female germ cell lineage

12.00 - 12.15

O01 Giuliano Stirparo - University of Cambridge, Cambridge, UK

Role of Oct4 in pre-implantation mouse development

12.15 - 12.30

 O02 Nuria Ferrandiz - University of Warwick, Coventry, UK

Chromosome ensheathing with endomembranes promotes missegregation

12.30 - 12.45

O02A Andrew Fielding – Lancaster University, Lancaster, UK

Dual screens reveal deubiquitylases that regulate KIFC1-dependent centrosome clustering and breast cancer cell survival

12.45 - 14.00  Lunch & Exhibition Viewing Time 13.00 onwards Poster Session ODD - Oculus Atruim (Main Campus)
14.00 - 17.00

Session 2: Organelle Bio-genesis

Chair: Jordan Raff

Session 2: Growth

Chair: Anna Philpott

14.00 - 14.30

S06 Monica Bettencourt-Dias - Instituto Gulbenkian de Ciência

The interplay between the centriole and the surrounding material in centrosome assembly and maintenance

S10 Alexandra Joyner - Sloan Kettering Institute, New York, USA

Growth regulation in the cerebellum during development and repair

14.30 - 15.00

S07 Pedro Carvalho – University of Oxford, Oxford, UK

Regulation of organelle biogenesis at the endoplasmic reticulum

S11 Jesus Gil - MRC LMS, London, UK

The senescence associated secretory phenotype (SASP) linking senescence, cancer and inflammation

15.00 - 15.15

O03 Gautam Dey - University College of London, UK

Nuclear division in closed mitosis requires local disassembly of the nuclear envelope

O05 John Robert Davis - The Francis Crick Institute, London, UK

Growth arrest in Drosophila histoblasts is uncoordinated and independent of tissue strain

15.15 - 15.30 Refreshment Break and Exhibition Viewing Time - Oculus Atrium (Main Campus)
15.30 - 16.00

S08 Sean Munro - MRC Laboratory of Molecular Biology, Cambridge, UK

Control of membrane traffic at the Golgi apparatus by coiled-coil proteins and Rab GTPases

S12 Aurelio Teleman - German Cancer Research Center (DKFZ), Heidelberg, Germany

Learning about human cell growth and proliferation from Drosophila development

16.00 - 16.30

S09 Jeremy Carlton - King’s & Crick, London, UK

ESCRT-III regulates nuclear envelope regeneration during mitotic exit

Adrienne Roeder – Cornell University, Ithaca, NY, US

Timing is everything: robustness in Arabidopsis floral organ size

16.30 - 16.45

O04 Amy Findlay – MCR HGU, Edinburgh, UK

Fam151b, homologue of C.elegans menorin, is necessary for photoreceptor survival in mice

O06 Andrew Jackson - MCR Human Genetics Unit, Edinburgh, UK

Being The Right Size: A Question Of Cell Fate?

17.00 - 18.30

Student & Post Doc Symposium 
Chairs: Charlotte Bailey and Joyce Yu

17.00 - 17.15

O07 Nestor Saiz, Sloan Kettering Institute, New York, USA

Tissue size determines lineage specification in the mouse blastocyst

17.15 - 17.30

O08 Laura E Hankins, University of Oxford, Oxford, UK

Coupled oscillators self-organise the assembly of centrioles

17.30 - 17.33

FT01 Silas Boye, University of Copenhagen, Copenhagen

Four simple rules that are sufficient to generate the mammalian blastocyst

17.33 - 17.36

FT02 Camilla Godlee, Imperial College London, London, UK

Membrane integration and post-Golgi trafficking of the Salmonella virulence protein SteD

17.36 - 17.39

FT03 Ghislain Gillard, MRC Laboratory of Molecular Biology, Cambridge, UK

A two-pronged mechanism generates an essential non-centrosomal microtubule array during tube budding morphogenesis in vivo

17.39 - 17.42

FT04 Susana Ponte, Universidade NOVA de Lisboa, Lisboa, Portugal

The role of mitochondrial dynamics in Drosophila wound healing

17.42 - 17.45

FT05 Wiliam Hill, ECSCRI, Cardiff University, Cardiff, UK

Elimination of Ras-transformed cells from the pancreas in vivo requires cell-cell interactions with normal cells and EphA2 dependent signalling.

17.45 - 17.48

FT06 Henry De Belly, University College London, UK

Crosstalk between cell surface mechanics and fate decisions in embryonic stem cells

18.00 - 18.15

O07A Daniel Toddie-Moore, University of Helsinki, Helsinki, Finland

Cell shape changes caused by BMP signalling lead to refinement of signalling range and cell fate determination in Drosophila wing veins

18.15 - 18.30

O08A Sabrina Ghadaouia, University of Manchester, Manchester, UK

Mitotic control of endothelial collective cell migration and blood vessel morphogenesis

18.30 - 19.30

PL04 Hooke Medal
Eugenia Piddini
, University of Bristol, Bristol, UK
How Cell Competition shapes tissue colonization and why it matters

Chair: Anne Ridley

19.30 - 20.30 Dinner - Rootes Restaurant (Rootes building)
20.30 - 20.40 CRUK - Developmental biology and childhood cancers
20.40 - 21.30

Waddington Medal

Chair: Ottoline Leyser

21.30 onwards Meet the Speakers and Drinks Reception - Panorama Suite, Rootes Building (Organised by Student & Post-Doc Reps)

Tuesday 9th April 2019

08.00 - 09.00

Funding Opportunities through CRUK

(Tea/coffee and hot breakfast rolls served)

9.00 - 12.30

Session 3: Migration and Invasion

Chair: Victoria Sanz-Moreno

Session 3: Non-autonomous reg of proliferation
Chair: Jean- Paul Vincent

9.00 - 9.30

S14 Claudia Linker - Kings College London

Notch coordinates cell cycle progression and migration behaviour leading to collective cell migration

S19 Yasuyuki Fujita - Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan

Cell competition between normal and transformed epithelial cells in mammals

9.30 - 10.00

S15 Anne Huttenlocher - University of Wisconsin-Madison, Madison, US

Imaging inflammation and wound repair

S20 Masazumi Tada - University College London, UK
Mechanism for oncogenic cell extrusion from embryonic epithelium

10.00 - 10.30

S16 Xavier Trepat - Institute For Bioengineering Of Catalonia, Barcelona, Spain

Mechanobiology of epithelial growth and folding

S21 Leonor Saúde - Instituto de Medicina Molecular, Lisboa, Portugal
Spinal cord regeneration: what can we learn with zebrafish?
10.30 - 11.00 Refreshment Break and Exhibition Viewing Time -  Oculus Atrium (Main Campus) 
11.00 - 11.30

S17 Jeffrey Pollard - University of Edinburgh, Edinburgh, UK

Macrophages: Bad Actors in Cancer

S22 JP Martinez-Barbera - Great Ormond Street UCL Institute of Child Health, London, UK

Paediatric brain tumours; the interface between development and cancer biology 
11.30 - 12.00

S18 Cedric Gaggioli – INSERM, Nice, France

Mechanical Regulation of Cancer Expansion; Tumor – stroma crosstalk in ECM remodeling and cancer cell dissemination

S23 Karen Guillemin - University of Oregon, Eugene, US

Teaming with microbes: lessons from the zebrafish intestine
12.00 - 12.15

O09 Patricia Pascual-Vargas – Institute of Cancer Research, London, UK

How RhoGEFs drive triple negative breast cancer cell invasion through the activation of YAP and TAZ. 

O11 Marc Amoyel – UCL, London, UK

The stem cell niche monitors cell cycle progression in its resident stem cells to maintain tissue homeostasis in the Drosophila testis.
12.15 - 12.30

O10 Caitlin Tolbert – Francis Crick Institute, London, UK

The Conformation of Tes Modulates RhoA Activity via p115RhoGEF

O12 Valeria Scagliotti - King's College London, UK

Over-expression of Delta-like homologue 1 (DLK1) in the pituitary gland positively modulates pituitary stem cell proliferation during organogenesis and results in increased organ size, progenitor number and somatotroph pool. 
12.30 - 14.00 Lunch & Exhibition Viewing Time - 13.00 onwards Poster Session EVEN Posters - Oculus Atrium 
14.00 - 18.00

Session 4: Trafficking

Chair: Steve Royle

Session 4: Mechanics and Morphogenesis

Chair: Jeremy Green

14.00 - 14.30

S24 Ulrike Eggert – King's College London, London, UK

Lipid composition influences cytoskeletal processes

S29 Elaine Emmerson - University of Edinburgh, Edinburgh, UK

SOX2 regulates acinar cell development in the salivary gland

14.30 - 15.00

S25 Volker Haucke - Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

Phosphoinositide regulation of endocytosis and nutrient signalling within the endolysosomal system

S30 Shankar Srinivas - University of Oxford, Oxford, UK

Deciphering epithelial cell movements during embryogenesis

15.00 - 15.15

O13 Hideyuki Shimizu – The University of Manchester, Manchester, UK

Notch regulation through membrane subcompartmentalisation on the endosomal surface.

O15 Shane Herbert – The University of Manchester, UK

mRNA targeting and local translation spatially directs tissue morphogenesis
15.15 - 15.30

O14 - Ashley Evans – The University of Bristol, Bristol, UK

Acute perturbation of retromer and SNX-BAR proteins lead to temporally resolved defects in endosomal cargo sorting

O16 Jordi Cayuson – The Francis Crick Institute, London, London UK

Mechanical tension downstream of Eph/Ephrin signalling regulates gene expression at rhombomere boundaries
15.30 - 16.00 Refreshment Break and Exhibition Viewing Time - Oculus Atrium (Main Campus)
16.00 - 16.30

S26 Maria Mittelbrunn - Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain

Mitochondrial failure in the immune system results in systemic inflammation and accelerated ageing

S31 Henrik Jonsson - Sainsbury Laboratory, University of Cambridge, Cambridge, UK

How many stem cells can you fit in a stem cell niche?

16.30 - 17.00 S27 Stephanie Kermorgant - Barts Cancer Institute, London, UK
c-Met endosomal signaling in cancer

S32 Madeline Lancaster - MRC Laboratory of Molecular Biology, Cambridge, UK

Modeling human brain development and connectivity in cerebral organoids

17.00 - 17.30

S28 Gia Voeltz - HHMI/University of Colorado, Boulder, USA

Title ER-mitochondrial membrane contact sites are a platform for morphological decision making

S33 Claudio Stern – University College London, London, UK

New insights into embryonic regulation and twinning

18.00 - 19.00 BSCB Annual General Meeting
BSDB Annual General Meeting
20.00 Onwards Conference Dinner - Panorama Suite (Rootes Building)

Wednesday 10th April 2019

9.00 - 11.00 

Session 5: Cell-Cell Communication

Chair: Stephen Robinson

Session 5: Germline & Early Development

Chair: Jenny Nichols

9:00 - 09:30

S34 Claus Jorgensen - CRUK Manchester Institute, Manchester, UK

Heterocellular interactions in the tumour microenvironment

S37 Peter Andrews – University of Sheffield, Sheffield, UK

The origin of acquired genetic variants of pluripotent stem cells

9.30 - 10.00

S35 Ilaria Malanchi - The Francis Crick Institute, London, UK

New protagonist of the metastatic environment

S38 Aditya Sankar - University of Copenhagen, Denmark

KDM4 is crucial for the maternal-zygotic transition and couples genome remodelling with stability in mammals

10.00 - 10.30

S36 Guillaume Charras - University College London, London, UK

On another plane: curling and buckling in epithelia

S39 Hansong Ma - Gurdon Institute, University of Cambridge, Cambridge, UK

The nuclear supervision of mitochondrial DNA transmission

10.30 - 10.45

O17 Sophie Adams - Queen Mary University London, London, UK

A novel role for centrosome amplification in the secretion and packaging of exosomes.

O19 Tim Weil – University of Cambridge, Cambridge, UK

Regulation of RNA through phase separation of Processing bodies during early Drosophila development  
10.45 - 11.00

O18 Federica Mangione – The Crick Institute, London, UK

Cross-talk between differentiating sensory organs and epithelial cells specify new cell types in Drosophila

O20 Makaski Kinoshita – University of Cambridge, Cambridge, UK

Formative Pluripotency
11.00 - 11.30 Refreshment Break - Oculus Atrium
11.30 - 12.30

PL05 Plenary BSDB - Sally Temple

Neural stem cells as a foundation for CNS development and Repair

Chair: Rita Sousa-Nunes

12.30 - 13.00 Packed Lunch for guests to depart - Oculus Atrium

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